GRPhIN: graphlet characterization of regulatory and physical interaction networks.

ABSTRACT:

Motivation

Graphs are powerful tools for modeling and analyzing molecular interaction networks. Graphs typically represent either undirected physical interactions or directed regulatory relationships, which can obscure a particular protein's functional context. Graphlets can describe local topologies and patterns within graphs, and combining physical and regulatory interactions offer new graphlet configurations that can provide biological insights.

Results

We present GRPhIN, a tool for characterizing graphlets and protein roles within graphlets in mixed physical and regulatory interaction networks. We describe the graphlets of mixed networks in Bacillus subtilis, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, and Saccharomyces ce

SUBMITTER: Barelvi A 

PROVIDER: S-EPMC12317317 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature