A Risk Stratification Model for Predicting Benefits of Intensive Blood Pressure Treatment: Analysis of the Systolic Blood Pressure Intervention Trial.

ABSTRACT: Current hypertension guidelines lack personalized strategies for blood pressure control. While the Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated benefits of intensive blood pressure lowering, identifying optimal candidates for such treatment remains challenging. We developed and validated a risk stratification model using data from 9139 SPRINT participants. The model incorporated 11 clinical variables through multivariable Cox regression analysis. Patients were stratified into low-, medium-, and high-risk groups. The study protocol was registered at ClinicalTrials.gov (NCT01206062). The model showed good discrimination with C-indices of 0.7354 (95% CI: 0.7065-0.7710) and 0.6894 (95% CI: 0.6545-0.7266) at 3 years for training and validation sets, respectively. Intensive t

SUBMITTER: Li N 

PROVIDER: S-EPMC12317323 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature