Initiation of Pregabalin vs Gabapentin and Development of Heart Failure.

ABSTRACT:

Importance

Both pregabalin and gabapentin are common nonopioid medications used to treat chronic pain, which affects up to 30% of patients. Because pregabalin has greater potency than gabapentin in binding to the α2δ subunit of the L-type calcium channel, pregabalin may be associated with an increased risk for heart failure (HF).

Objective

To compare incident hospitalizations and emergency department (ED) visits for HF among new users of pregabalin vs gabapentin among Medicare beneficiaries with noncancer chronic pain.

Design, setting, and participants

This retrospective cohort study included data collected between January 1, 2015, and December 21, 2018, for Medicare beneficiaries aged 65 to 89 years with chronic noncancer pain and without a history of HF and terminal

SUBMITTER: Park EE 

PROVIDER: S-EPMC12317353 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature