Upregulation of YY1/EZH2 and MLH1 as Therapeutic Targets for Adult T-Cell Leukemia/Lymphoma.

ABSTRACT: The clinical and genetic presentation of adult T-cell leukemia/lymphoma (ATLL) ranges from indolent to aggressive, making it difficult to identify common therapeutic targets. Inhibiting EZH1/2 suppresses ATLL through epigenetic modulation; however, the diverse genetic background of ATLL precludes its mode of action from being clearly elucidated. We conducted single-cell RNA sequencing (scRNA-seq) of primary ATLL cells and identified an epigenetic regulative axis. First, flow cytometry showed that the proliferative potential of CADM1⁺ HTLV-1-infected cells ranges from stable to treatment-required. Second, scRNA-seq identified a CCR4⁺CD48^- cluster, the population of which increased in treatment-required patients. In silico promoter analysis of this cluster id

SUBMITTER: Shimizu T 

PROVIDER: S-EPMC12317392 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature