Risk Factors for Corticosteroid-associated Osteonecrosis in Children: A National Database Study.

ABSTRACT:

Background

Corticosteroid-associated osteonecrosis presents a risk for severe pain and joint collapse. While the relationship between corticosteroid treatment and osteonecrosis in pediatric patients is well-documented, less is known about which patients are at greatest risk across medical conditions. The purpose of this study was to identify high-risk pediatric populations for developing osteonecrosis following corticosteroid treatment across autoimmune, inflammatory, and oncologic conditions.

Methods

The Merative MarketScan Research Databases (2007-2022) were queried to identify pediatric patients with an outpatient oral or intravenous corticosteroid prescription. Demographic, clinical, and prescription differences between osteonecrosis and non-osteonecrosis patients were a

SUBMITTER: Smith GB 

PROVIDER: S-EPMC12317409 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature