Joint associations of pre-diabetes, pre-hypertension, and pre-dyslipidemia with cardiovascular and metabolic disease progression.

ABSTRACT:

Background

Pre-diabetes, pre-hypertension, and pre-dyslipidemia are early metabolic abnormalities associated with cardiovascular disease (CVD), but their joint effects on CVD and metabolic disease progression remain unclear. This study examines their joint associations and interactions on CVD and progression to diabetes, hypertension, and dyslipidemia in Chinese adults aged ≥ 45 years.

Methods

A prospective cohort of 3405 adults (mean age 57.07 years, 49.9% women) from the China Health and Retirement Longitudinal Study (CHARLS) was analyzed. Pre-diabetes, pre-hypertension, and pre-dyslipidemia were defined as elevated but subclinical thresholds for blood pressure, glucose, and lipids. Cox model was used to assess associations between the number of pre-disease risk factors (0

SUBMITTER: Ma C 

PROVIDER: S-EPMC12317467 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature