Dysregulated proliferation and immune response induced by estrogen in Egr1 knockout uterus are similar to those in immature uterus.

ABSTRACT:

Background

A balance between estrogen (E2) and progesterone (P4) is vital for a successful pregnancy, and an imbalance between these two hormones yields female infertility. E2 mediates uterine receptivity and regulates endometrial growth, the immune system, and hormone signaling by rapidly inducing early growth response 1 (EGR1). However, the precise mechanism by which EGR1 regulates E2-mediated uterine growth remains unclear. This study examined the transcriptional signatures of ovariectomized (OVX) Egr1 knockout (KO) mice compared to those of wild-type (WT) mice to clarify the function of EGR1 in the E2-dependent uterine response.

Results

Egr1 KO uteri exhibited an impaired E2 response, with significant changes in the expression of the key genes Bgn, c-Kit, Ripor2, and Arg

SUBMITTER: Jo GH 

PROVIDER: S-EPMC12317513 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature