Monosodium glutamate exacerbated the lipopolysaccharide-induced reproductive toxicity of male Wistar rats.

ABSTRACT:

Background

Monosodium glutamate (MSG) is a common food additive that has been linked to oxidative stress and reproductive dysfunction. Lipopolysaccharide (LPS), a bacterial endotoxin, is known to induce systemic inflammation, leading to oxidative damage and hormonal disruption. This study investigated whether MSG exacerbates LPS-induced testicular toxicity in male Wistar rats via oxidative stress and endocrine dysfunction.

Methods

Twenty-eight male Wistar rats were divided into four groups (n = 7): control (distilled water), MSG (1500 mg/kg), LPS (250 µL/kg), and a combination of MSG + LPS. MSG was used in the background of LPS to model a real-life "double-hit" exposure where dietary and microbial toxins co-exist. We hypothesised that MSG would amplify LPS-induced reproducti

SUBMITTER: Ogunro OB 

PROVIDER: S-EPMC12317537 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature