Blood plasma proteome-wide association study implicates novel proteins in the pathogenesis of multiple cardiovascular diseases.

ABSTRACT:

Background

Cardiovascular diseases (CVD) are the leading cause of global mortality, yet current treatments benefit only a subset of patients. To identify new potential treatment targets, we conducted the first proteome wide association study (PWAS) for 26 CVDs using plasma proteomics data from the largest cohort to date (53,022 individuals in the UK Biobank Pharma Proteomics Project (UKB-PPP)).

Methods and results

We calculated single nucleotide polymorphism (SNP)-protein weights using the UKB-PPP dataset and integrated these weights with genome-wide association study (GWAS) summary statistics for 26 CVDs across three categories (16 cardiac, 5 venous, and 5 cerebrovascular diseases) in up to 1,308,460 individuals. PWAS was performed using the Functional Summary-based Imputat

SUBMITTER: Wang JH 

PROVIDER: S-EPMC12317611 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature