Metabolic engineering of Saccharomyces cerevisiae for neoxanthin production.

ABSTRACT:

Background

Xanthophylls, a subclass of oxygenated carotenoids, are highly valued for their wide range of applications in the food and pharmaceutical industries, particularly due to their antioxidant properties and potential health benefits. Among these, neoxanthin, a less studied xanthophyll, has demonstrated significant therapeutic potential, including antioxidant and anticancer activities. Neoxanthin is also the primary precursor for the synthesis of other valuable compounds, such as fucoxanthin and β-damascenone, which are important in the cosmetic and pharmaceutical sectors.

Results

In this study, we report the first heterologous production of neoxanthin in Saccharomyces cerevisiae through a combination of metabolic and enzyme engineering. First, a S. cerevisiae strain w

SUBMITTER: Arenas N 

PROVIDER: S-EPMC12317632 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature