Network control theory uncovers aberrant connectome controllability in trigeminal neuralgia.

ABSTRACT:

Background

Trigeminal neuralgia (TN) involves complex neural network alterations beyond the trigeminal system. Network Control Theory (NCT) offers a novel framework to quantify how brain network architecture constrains neural dynamics. This study investigated structural network controllability in TN to elucidate disease-specific alterations in brain network control properties.

Methods

Eighty-two TN patients and 42 healthy controls (HCs) underwent diffusion tensor imaging. Structural connectomes were constructed using deterministic tractography and parcellated with the Brainnetome atlas. Average controllability (AC), reflecting the ease of driving networks toward accessible states, and modal controllability (MC), indicating the capacity for difficult state transitions, were c

SUBMITTER: Chu T 

PROVIDER: S-EPMC12317636 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature