Electroacupuncture alleviates sciatic nerve injury in sciatica rats by regulating BDNF and NGF levels, myelin sheath degradation, and autophagy.

ABSTRACT: The aim of this study is to investigate the role of electroacupuncture in alleviating sciatic nerve injury. A rat model for sciatic nerve crush injury was established using clamping forceps, and then electroacupuncture at the "Zusanli" (ST36) and Huantiao" (GB30) acupoints was performed. The values of sciatic functional index (SFI), paw withdrawal latency (PWL), and paw withdrawal threshold (PWT) were evaluated. The mRNA expression of neurotrophic factors in nerve tissues was examined by RT-qPCR analysis. Morphometric analyses of transverse sections at the sciatic nerve distal to injury were performed 8 weeks post-injury. Immunofluorescence staining of sciatic nerve and western blotting were performed to measure the expression of myelin protein zero (MPZ) and autophagy markers. The experim

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12317652 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature