Mild Duodenal Mucosal Injury and Increased Type I Interferon Signaling Are Preludes to Celiac Disease.

ABSTRACT: Celiac disease (CeD) is an immune-mediated chronic enteropathy caused by gluten exposure in genetically susceptible individuals. The characteristic histologic features of CeD include increased intraepithelial lymphocytes and villous atrophy. Clinically, a subset of individuals with elevated concentrations of serum tissue transglutaminase (TTG) antibodies have intact duodenal villous architecture at initial endoscopy and biopsy but then progress to CeD over time while on gluten-containing foods. We hypothesized that these rare potential CeD cases with progression can allow us to interrogate histologic and molecular signatures to predict those who subsequently develop CeD and to study the final cascade into the overt lesions of CeD. We retrospectively identified 16 children over a 10-year pe

SUBMITTER: Ma C 

PROVIDER: S-EPMC12317670 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature