Associations of age at T2D detection with hemoglobin A1c in a national inception cohort of U.S. Veterans with diabetes.

ABSTRACT:

Objective

To investigate associations of age at type 2 diabetes (T2D) detection with HbA1c.

Research design and methods

We examined associations of early-onset T2D (age of detection 20-39 years) and age at T2D detection with HbA1c in Veterans with incident T2D (1/1/2008-12/31/2016; n = 851,302).

Results

About 3 % (n = 22,649) of men and 11 % (n = 5,117) of women had early-onset T2D. Compared to men with later-onset T2D, men with early-onset T2D had a 0.71 (95 %CI 0.69,0.73) greater HbA1c after detection, a 0.78 (95 %CI 0.77,0.80) greater mean HbA1c, and a 0.05 (95 %CI 0.04,0.05) greater coefficient of variation (CV). Each 10-year decrease in age was associated with greater HbA1c after detection, mean HbA1c, and HbA1c CV (β 0.21 (95 %CI 0.21,0.21), 0.25 (95 %CI 0.24,0.

SUBMITTER: Avramovic S 

PROVIDER: S-EPMC12317824 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature