MicroRNA based Prediction of Posthepatectomy Liver Failure and Mortality Outperforms Established Markers of Preoperative Risk Assessment.

ABSTRACT:

Background

Posthepatectomy liver failure (PHLF) continues to be the most significant factor-determining outcome after hepatic resection, accounting for nearly half of postoperative mortality. In this study, we evaluated whether a newly developed commercially available test measuring circulating microRNAs (miRs) could predict PHLF and compared it with other established liver function tests.

Patients and methods

A total of 329 patients undergoing liver resection were included and postoperative outcome was assessed. Our previously described P-score, calculated on the basis of three circulating microRNAs (miR-122-5p, miR-192-5p, miR-151a-5p) using the hepatomiR^® CE-IVD test, was evaluated and compared with other predictors of PHLF, namely indocyanine green (ICG)-clear

SUBMITTER: Kern AE 

PROVIDER: S-EPMC12317877 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature