Revealing the regulatory role of lncRNAs SNHG1 and CRNDE on Th17/Treg imbalance in diabetic kidney disease.

ABSTRACT: Diabetic kidney disease (DKD) is a chronic inflammatory condition associated with diabetes that can progress to end-stage renal disease (ESRD). However, our knowledge about the epigenetic regulatory mechanism underlying the imbalance of Th17/Treg cells in inflammatory responses remains unclear. Therefore, our aim in this study was to identify regulatory lncRNAs involved in differentiating Th17/Treg cell lines. Regulatory lncRNAs associated with DKD were identified by analyzing the GSE43005 and GSE142025 datasets from the GEO database and conducting a comprehensive literature review. After identifying differentially expressed genes (DEGs), we validated our bioinformatics results using real-time PCR. In our study, ninety individuals were recruited and assigned to four groups: 30 with Type 2

SUBMITTER: Hosseini SA 

PROVIDER: S-EPMC12317880 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature