Deciphering the molecular clock: exploring molecular mechanisms and genetic influences on skin ageing.

ABSTRACT: Skin ageing is a multifaceted process influenced by both intrinsic genetic factors and extrinsic environmental exposures. This review explores the genetic variants and molecular mechanisms underlying skin ageing phenotypes, while identifying gaps in current research to inform future studies. A systematic search of the Scopus and Web of Science databases was conducted, with articles screened based on criteria including a focus on human genetic association studies and indexing in either Scopus or the Institute for Scientific Information (ISI) Web of Science. The quality of included studies was assessed using the Q-Genie tool. Thirteen studies met the inclusion criteria, collectively analysing 115 single nucleotide polymorphisms (SNPs) across 99 genes. The OCA2 gene emerged as the most freque

SUBMITTER: Ng HY 

PROVIDER: S-EPMC12317886 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature