Adjuvant External Beam Radiotherapy Reduces Local Recurrence in Poorly Differentiated Thyroid Cancer : A Multicenter Retrospective Cohort Study Describing Outcomes in the Treatment of Resectable Poorly Differentiated Thyroid Cancer.

ABSTRACT:

Background

Poorly differentiated thyroid carcinoma (PDTC) accounts for 5% of all thyroid cancers and is responsible for a large proportion of thyroid cancer-related deaths. The optimal treatment approach is not clear. This study aimed to evaluate the effect of postoperative intensity-modulated radiotherapy (IMRT) on the treatment of resectable PDTC. Additionally, treatment-related morbidity, characteristics of ¹³¹I-refractory disease, and factors affecting survival were assessed.

Methods

The study included consecutive PDTC cases from 1997 to 2018, defined according to Turin criteria and treated in two tertiary referral centers. Surgery, IMRT, ¹³¹I, and systemic therapies were administered based on multidisciplinary team recommendations. The primary stud

SUBMITTER: Jonker PKC 

PROVIDER: S-EPMC12317901 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature