Integrating Magnetic Resonance Chemical Shift Imaging for Localized Prostate Cancer Risk Stratification on the Basis of the Impact of Periprostatic Brown Adipocytes Within Tumor Microenvironment.

ABSTRACT:

Background

We sought to characterize periprostatic adipose tissue (PPAT) with magnetic resonance imaging (MRI) featuring water-to-oil ratio (R^WO) to detect brown adipocyte (BAT).

Patients and methods

Between November 2021 and September 2023, 21 localized patients with prostate cancer were studied, categorized as low (n = 4), intermediate (n = 4), and high risk (n = 13). We utilized MRI to analyze the water-only signal and fat-only signal. R^WO was used to predict the risk stratification. Tissue samples, including periprostate fat, were collected during surgery, processed, and stained with hemotoxylin and eosin (H&E) for microscopic analysis. Periprostate adipose cell supernatants were used to treat cancer cells (PC3 and LNCaP) in vitro.

Results

We

SUBMITTER: Shen CY 

PROVIDER: S-EPMC12317911 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature