Source control in bloodstream infections in patients with sepsis, septic shock, or requiring ICU admission: a scoping review with recommendations for standardizing research.

ABSTRACT:

Background

Bloodstream infections (BSI) account for 15% of intensive care unit (ICU) infections, often causing sepsis with mortality rates up to 50%. Source control (SC), encompassing interventions to reduce bacterial or fungal load and prevent infection spread, is a critical yet under-investigated component of management.

Objectives

This scoping review examines SC definitions, interventions, timing, adequacy, and outcomes in BSI literature in patients with sepsis, septic shock, or ICU admission, and offers a proposal for standardized reporting.

Methods

We searched Medline, EMBASE, and Cochrane Library for studies on adult BSI addressing SC in populations with ≥ 50% ICU admission, ≥ 75% sepsis, or ≥ 25% septic shock, extracted and reported data following established g

SUBMITTER: Tabah A 

PROVIDER: S-EPMC12317914 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature