Validation of Invasive Area for Predicting Sentinel Node Status and Survival in Primary Cutaneous Melanoma.

ABSTRACT:

Background

Two-dimensional histologic features have demonstrated independent prognostic value for survival in primary cutaneous melanoma, but their predictive value for sentinel node (SN) status has yet to be validated. We aimed to demonstrate the predictive value of the previously described calculated tumor area (CTA), and the novel Simplified Breslow Area (SBA), for SN metastasis and survival.

Materials and methods

A total of 177 primary melanomas were assessed for standard histological characteristics, maximum invasive width (IW) of the primary tumor and CTA. We simplified CTA measurement by transforming IW with Breslow thickness (BT) [ln(IW) + ln (BT)], yielding SBA. Multivariate analysis was undertaken to assess the performance of CTA and SBA, respectively, as independe

SUBMITTER: Orme SE 

PROVIDER: S-EPMC12317915 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature