Smoking and alcohol specific alterations in miRNA expression in head and neck squamous cell carcinoma.

ABSTRACT: Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent cancers worldwide with a high mortality in the advanced setting. Smoking and excessive alcohol consumption are major risk factors for the occurrence of HNSCC and contribute to a poor prognosis with continued use. In this study, we sought to identify the miRNAs that are dysregulated in response to smoking and alcohol consumption. miRNA-Seq datasets of HNSCC patients from The Cancer Genome Atlas (TCGA) were queried and included patients with (i) smoking exposure only (ii) alcohol consumption only (iii) exposure to both smoking and alcohol and (iv) no history of smoking or drinking alcohol. Our analysis led to the identification of 43 and 26 miRNAs that were differentially expressed in HNSCC patients with smoking only

SUBMITTER: Bhat MY 

PROVIDER: S-EPMC12317938 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature