Identification of mitochondria-related biomarkers for acute respiratory distress syndrome.

ABSTRACT: Mitochondria-related genes (MRGs) are considered screening MRGs as biomarkers for important therapeutic targets, but their role in acute respiratory distress syndrome (ARDS) remains unclear. This study aimed to identify MRGs-related biomarkers for ARDS. Intersection of 2030 MRGs with 343 differentially expressed genes (DEGs) between sepsis-non-ARDS and sepsis-ARDS group yielded 20 MRGs-related DEGs enriched in mitochondrion-related pathways. Monocytes, T cells, natural killer (NK) T cells, NK cells, and innate lymphoid cells (ILCs) were screened as candidate key cell types. SLC2A1 and IFI27 were defined as biomarkers; naive B cells, resting NK cells, and naive CD4 T cells, as differential immune cells; and monocytes, as the key cell type, subdivided into the CD14 and CD16 subtypes. The sep

SUBMITTER: Hongyuan H 

PROVIDER: S-EPMC12318068 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature