The cycle gene is essential for both daily responses and seasonal reproduction in the Northern house mosquito, Culex pipiens.

ABSTRACT: The insect circadian clock synchronizes daily activities, such as feeding, eclosion, and mating to diurnal light:dark cycles, while the photoperiodic clock synchronizes development and reproduction to the appropriate season. Despite mounting evidence that the circadian and photoperiodic timekeeping systems are linked, it is unclear whether the circadian clock as a whole or individual genes within the circadian clock are responsible for measuring daylength, releasing hormones and/or inducing diapause phenotypes. To interrogate the role of a core circadian transcription factor, cycle, in mediating both seasonal and daily behaviors we used CRISPR/Cas-9 genome editing to introduce a deletion mutation into cycle in the Northern house mosquito, Culex pipiens. Females homozygous for this deletion

SUBMITTER: Wolkoff M 

PROVIDER: S-EPMC12318080 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature