Multimodal tumor microenvironment signature of colorectal cancer for prediction prognosis and chemotherapy benefit.

ABSTRACT: The current tumor‒node‒metastasis (TNM) staging system cannot provide sufficient information for prognosis and chemotherapy benefits in patients with colorectal cancer (CRC). The tumor microenvironment plays a critical role in disease progression and therapeutic response. Here, we developed and validated a multimodal tumor microenvironment signature of CRC (MTMS_CRC) using 1314 CRC patients to enhance prognosis and chemotherapy benefit predictions. We found that the MTMS_CRC is an independent predictor of prognosis. Furthermore, incorporating the MTMS_CRC and clinicopathological characteristics into the integrated nomograms significantly outperformed traditional models and the TNM staging system. Shapley values identified the MTMS_CRC as the most imp

SUBMITTER: Jiang W 

PROVIDER: S-EPMC12318095 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature