High performance data integration for large-scale analyses of incomplete Omic profiles using Batch-Effect Reduction Trees (BERT).

ABSTRACT: Data from high-throughput technologies assessing global patterns of biomolecules (omic data), is often afflicted with missing values and with measurement-specific biases (batch-effects), that hinder the quantitative comparison of independently acquired datasets. This work introduces batch-effect reduction trees (BERT), a high-performance method for data integration of incomplete omic profiles. We characterize BERT on large-scale data integration tasks with up to 5000 datasets from simulated and experimental data of different quantification techniques and omic types (proteomics, transcriptomics, metabolomics) as well as other datatypes e.g., clinical data, emphasizing the broad scope of the algorithm. Compared to the only available method for integration of incomplete omic data, HarmonizR,

SUBMITTER: Schumann Y 

PROVIDER: S-EPMC12318123 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature