Design, synthesis and bioactivity evaluation of phosphinanes as potential anticancer agents.

ABSTRACT: The development of novel anticancer agents is crucial to the ongoing effort to combat cancer. In this study, six-membered phosphorus heterocycles (phosphinanes) were designed, synthesized, and evaluated as potential antiproliferative agents. A series of novel phosphinane derivatives was obtained through structural modifications of 1-phenylphosphinane 1-oxide and 1-phenylphosphinan-4-one 1-oxide, achieving high overall yields. The dearomatization of the phenyl group attached to the phosphorus atom is a pivotal step in the P-substituent modification. The synthesized compounds, differing in steric and electronic properties, were assessed for in vitro cytotoxicity against colon (SW480, SW620, HCT116) and prostate (PC3) cancer cell lines. Among them, three compounds (2, 8, and 11) exhibited act

SUBMITTER: Lastawiecka E 

PROVIDER: S-EPMC12318127 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature