Leveraging chromatin packing domains to target chemoevasion in vivo.

ABSTRACT: Cancer cells exhibit a remarkable resilience to cytotoxic stress, often adapting through transcriptional changes linked to alterations in chromatin structure. In several types of cancer, these adaptations involve epigenetic modifications and restructuring of topologically associating domains. However, the underlying principles by which chromatin architecture facilitates such adaptability across different cancers remain poorly understood. To investigate the role of chromatin in this process, we developed a physics-based model that connects chromatin organization to cell fate decisions, such as survival following chemotherapy. Our model builds on the observation that chromatin forms packing domains, which influence transcriptional activity through macromolecular crowding. The model accuratel

SUBMITTER: Frederick J 

PROVIDER: S-EPMC12318189 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature