Changes in brain network dynamics during functional/dissociative seizures: An exploratory pilot study on EEG microstates.

ABSTRACT: The pathophysiology of functional/dissociative seizures (FDS), also known as psychogenic nonepileptic seizures, remains incompletely understood. Current theories suggest that ictal changes in self-awareness and behavioural control are likely related to arousal-mediated disruptions of brain network dynamics, but direct electrophysiological evidence is scarce. In a proof-of-concept, the second of its kind pilot study, we explored ictal changes in EEG microstates - quasi-stable patterns of electrical activity of 50-70 ms duration that represent fundamental building blocks of large-scale brain network dynamics. Across a sample of 13 FDS patients, four microstates yielded a high mean global explained variance of 76.2 % and qualitatively resembled the well-established "canonical" microstate map

SUBMITTER: Kucikiene D 

PROVIDER: S-EPMC12318286 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature