Injectable composite microspheres/hydrogel membranes for Achilles tendon regeneration.

ABSTRACT: Tendon injury is a common condition with potential for disability. Severe injuries such as tendon rupture often require surgical suturing to restore their structure and function. The healing process of tendons is a critical factor affecting clinical outcomes; however, their poor blood supply and low cellular density limit self-regeneration capabilities. This leads to insufficient quality and biomechanical properties of the repaired tendon, playing a significant role in the high rate of re-rupture in clinical practice. Tendon healing involves endogenous (tenocyte proliferation) and exogenous (fibroblast invasion) mechanisms. An imbalance between these two mechanisms often leads to postoperative adhesions, which significantly impacts clinical efficacy. Thus, this project aims to design an in

SUBMITTER: Yang M 

PROVIDER: S-EPMC12318288 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature