Type 1 diabetes mellitus (T1DM) does not affect whole blood responses to alginate-based microspheres despite plasma lipid and glucose differences.

ABSTRACT: Encapsulation of insulin-producing cells holds significant therapeutic potential for treating type 1 diabetes (T1DM). The impact of diabetic conditions on host responses is not well understood. This study is the first to compare ex-vivo whole blood responses to alginate microbeads in T1DM subjects versus healthy controls. Nineteen T1DM and 27 healthy controls were included. Alginate microbeads varying in guluronic acid content (68 % and 47 % G), sulfated alginate/alginate ratios (10/90 and 20/80), or containing poly-L-lysine were characterised regarding activation of coagulation, complement, and inflammatory cytokine release in whole blood. Responses to heat-killed microbes (E. coli, S. pneumoniae, M. tuberculosis, and C. albicans) and immune agonists (TLR ligan

SUBMITTER: Vasuthas K 

PROVIDER: S-EPMC12318296 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature