Comprehensive Robustness Evaluation of Proton and Carbon-Ion Plans in Thoracic Cancer Treatment.

ABSTRACT:

Purpose

To evaluate the impact of setup errors, range uncertainty, and respiratory motion on dose distributions for clinically delivered pencil beam scanning proton and carbon-ion plans.

Materials and methods

A retrospective analysis was conducted on 23 lung cancer and trachea adenoid cystic carcinoma patients who received treatment at our center. Plans were generated using Syngo with planning target volume-based optimization. Dose reconstruction was performed using TReatment planning for Particles 4D. The plans robustness evaluation was performed using two methods: a worst scenarios conventional evaluation (WSCE) with 21 scenarios and a worst scenarios statistical evaluation (WSSE) with 100 randomly sampled scenarios. On top of the 3D evaluation considering setup error and

SUBMITTER: Sheng Y 

PROVIDER: S-EPMC12318338 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature