Properties of CD8 T-cell-recognized neoantigens in different tumor types.

ABSTRACT:

Background

Neoantigen-based immunotherapies rely on computational tools predicting peptide immunogenicity based on properties such as its expression level, binding affinity to human leukocyte antigen (HLA), likelihood of proteasomal cleavage and dissimilarity from wild-type peptide. However, current datasets are scarce and limited to highly mutated tumor types such as melanoma and lung cancer, leaving uncertainty about the value of these properties in other tumor types.

Materials and methods

To investigate this, we retrospectively analyzed the properties of immunogenic neoantigens identified in CD8 T-cell recognition screens of predicted neoantigens in tumor-infiltrating lymphocytes (TILs) from 12 melanoma patients and peripheral blood mononuclear cells (PBMCs) from 14 patie

SUBMITTER: Ketelaars SLC 

PROVIDER: S-EPMC12318345 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature