Photoprotective, Antioxidant and Anti-Inflammatory Effects of Aged <i>Punica granatum</i> Extract: In Vitro and In Vivo Insights.

ABSTRACT: Ultraviolet (UV) radiation is a primary environmental factor contributing to skin damage, including erythema, hyperpigmentation, and photoaging. This study evaluates the photoprotective, antioxidant, and anti-inflammatory effects of aged Punica granatum extract (APEx), chosen for its richness in polyphenols, to assess its potential as a natural therapeutic agent in skin care. APEx was analyzed for its polyphenolic composition using high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS). Its antioxidant capacity was measured via the Trolox Equivalent Antioxidant Capacity (TEAC) assay. Cellular studies on HaCaT keratinocytes and Caco-2 epithelial cells assessed the extract's antioxidant and anti-inflammatory effects under stress conditions. A randomized, doubl

SUBMITTER: Ikeda Y 

PROVIDER: S-EPMC12318356 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature