Serum metabolomics in pulmonary sarcoidosis: metabolic signatures across prognoses.

ABSTRACT:

Background

Sarcoidosis is a systemic inflammatory disease, primarily affecting the lungs, with a prognosis that varies widely among patients. While some patients recover spontaneously after diagnosis, others experience disease progression. Currently, the metabolomic profile associated with pulmonary sarcoidosis and its different clinical outcomes remains poorly understood.

Methods

Serum samples from 29 pulmonary sarcoidosis patients and 10 healthy controls were analyzed using untargeted UPLC-MS/MS metabolomics. Univariate and multivariate analyses identified differentially expressed metabolites, followed by pathway enrichment to evaluate their biological relevance. Patients were further stratified into self-healing (n = 11) and progressive (n = 18) subgroups based on prognos

SUBMITTER: Zhu D 

PROVIDER: S-EPMC12318405 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature