Targeting the mTOR Signaling Pathway Through miR-100 and miR-101 in De Novo Acute Myeloid Leukemia: Implications for Therapeutic Intervention.

ABSTRACT:

Background

Microribonucleic acid (MicroRNAs/miRNAs) play a significant role in cancer progression by changing cellular functions through the modulation of protein expressions. The potential of different miRNAs to alter the expression of the mammalian target of rapamycin (mTOR)/protein kinase B (PKB or AKT)/phosphatidylinositol-3-kinase (PI3K) signaling cascade, a key pathway in the progression of acute myeloid leukemia (AML), has been demonstrated across different types of cancers.

Aims

This study aims to explore the effects of miR-100 and miR-101 on the mTOR/AKT/PI3K signaling pathway in AML.

Methods and results

Initially, we employed the TargetScan, miRDB, and miRanda databases to identify the target proteins of miR-100 and miR-101. Following a comprehensive analysi

SUBMITTER: Kargar M 

PROVIDER: S-EPMC12318680 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature