Association between triglyceride glucose-body mass index and acute kidney injury and renal replacement therapy in critically ill patients with sepsis: analysis of the MIMIC-IV database.

ABSTRACT:

Background

Previous studies have linked kidney damage to insulin resistance (IR), yet the association between triglyceride glucose-body mass (TyG-BMI) index, a reliable marker of IR, and acute kidney injury (AKI) remains unclear.

Methods

Patient data were collected from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. AKI was set as the primary endpoint, and renal replacement therapy (RRT) was set as the secondary endpoint to represent the progression of AKI. TyG-BMI index and study endpoints were analyzed using Cox regression and restricted cubic spline (RCS) analyses.

Results

A total of 1,117 patients with sepsis were enrolled, of whom 559 (50.0%) developed AKI. The result of Cox regression revealed that the TyG-BMI index was closely related t

SUBMITTER: Wang S 

PROVIDER: S-EPMC12318719 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature