Comparison of single-spin to double-spin platelet-rich plasma centrifugation methods in the treatment of androgenic alopecia: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Androgenic alopecia (AGA) is the most common hair loss disease, caused by a combination of genetic factors and hormonal imbalances. Platelet-rich plasma (PRP) therapy has gained significant recognition in treating AGA, but optimal treatment protocol regarding centrifugation techniques has yet to reach a standardized consensus. We aim to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) to compare the efficacy of single-spin versus double-spin centrifugation protocols for PRP in patients with AGA.

Methods

We searched PubMed, Embase, and Cochrane for RCTs comparing single-spin to double-spin PRP in AGA patients. The primary endpoint was the final platelets count after centrifugation. Secondary endpoints included improvement in hair

SUBMITTER: Ghanem L 

PROVIDER: S-EPMC12318733 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature