Significance of FXa and its receptor PAR2 for the growth of colon cancer cells <i>in vitro</i> and <i>in vivo</i>.

ABSTRACT: Colon cancer is among the most common cancer types worldwide. Signaling pathways that control cell proliferation and migration play a crucial role in its progression. The G-protein-coupled protease-activated receptors (PARs) are associated mediators in this process. Both activated coagulation factors thrombin and FXa are capable of activating PARs. While thrombin, beyond its intrinsic role in hemostasis, primarily activates PAR1, FXa mediates its cellular effects independently via PAR2. Although the role of thrombin and PAR1 activation in cancer development has been established for some time, the impact of FXa-PAR2 on tumor progression represents a relatively novel area of investigation. Therefore, the current study was conducted to examine the role of FXa and PAR2 signaling in colon cance

SUBMITTER: Meyer U 

PROVIDER: S-EPMC12318734 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature