Macrophage transfer promotes intestinal mucosal healing by encouraging transit-amplifying cell expansion in mice.

ABSTRACT: Cellular therapy, including stem cell injections, has been proved to be therapeutic for patients with inflammatory bowel disease (IBDs), showing promising outcomes of disease progression. However, challenges of stem cell therapy remain, such as Crohn's disease with complex fistula, thus limiting its use and requiring another cellular therapy target for efficacy. Alternatively, macrophages have been reported to enhance recovery of damaged intestinal epithelial barriers during resolution of IBDs; thus, utilizing macrophage as a therapeutic strategy was hypothesized. In this study, we compared the regenerative capacity of wild-type and Tnf^- macrophages to validate the potential of genetically modified macrophages with low-inflammatory properties. Our findings demonstrate tha

SUBMITTER: Kang DS 

PROVIDER: S-EPMC12318747 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature