A multimodal nomogram for benign-malignant discrimination of lung-RADS ≥4A nodules: integration of oxygen enhanced zero echo time MRI, CT radiomics, and clinical factors.

ABSTRACT:

Background and objective

Lung-RADS ≥4A nodules require urgent intervention. Low-dose CT (LDCT), the primary screening tool, involves cumulative radiation exposure-critical for patients with serial scans. Oxygen-enhanced zero-echo time MRI (OE-ZTE-MRI) shows potential for lung nodule evaluation. However, its additive value when combined with CT radiomics and clinical factors for Lung-RADS ≥4A nodules remains unproven. This study aimed to develop a preoperative prediction model integrating OE-ZTE-MRI/CT radiomics and clinical factors for benign-malignant discrimination of Lung-RADS ≥4A nodules and compare its performance against single-modality models.

Methods

99 nodules from 84 prospectively enrolled patients undergoing both LDCT and OE-ZTE-MRI were included. Nodule boundarie

SUBMITTER: Yan T 

PROVIDER: S-EPMC12318770 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature