Neuromedin U Activation of Group 2 Innate Lymphocytes Exacerbates Local Inflammation of Nasal Mucosa in Allergic Rhinitis.

ABSTRACT:

Purpose

Allergic rhinitis (AR) is no longer considered an immune dysregulation disorder but rather a neuroimmune disorder regulated by neuronal signals. However, the mechanisms underlying these effects remain unclear. Therefore, we evaluated whether the local nasal mucosa is regulated by neuroimmune signals during nasal allergic reactions.

Methods

We identified genes that were differentially expressed between patients with AR and healthy controls using GSE46171 gene chip data. Expression levels of neuromedin U (NMU), NMU receptor 1 (NMUR1), and group 2 innate lymphoid cells (ILC2s) in the nasal mucosa were determined the impacts of NMU on patients with AR were assessed. An AR animal model was established to observe the effects of local NMU intervention on local and systemic

SUBMITTER: Qi X 

PROVIDER: S-EPMC12318804 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature