Multi-omics integration analysis identifies INPP4B as a T-cell-specific activation suppressor.

ABSTRACT:

Background

Naïve T cells are maintained in a quiescent state prior to activation. As inappropriate T-cell activation can lead to impaired immune tolerance and autoimmune diseases, the transition from quiescence to activation must be under strict regulation. Despite its importance, the mechanisms underlying the maintenance of the quiescent state remain incompletely understood.

Methods and results

Through multi-omics integration analysis, we reveal that INPP4B, a phosphatase of the phosphoinositide 3-kinase pathway, is highly expressed specifically in T cells and is involved in suppressing T-cell activation and maintaining quiescence. Our findings uncover that INPP4B forms a T-cell-specific chromatin interaction domain and exhibits high expression levels in quiescent T cells.

SUBMITTER: Peng T 

PROVIDER: S-EPMC12318829 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature