The pyroptosis-related gene signature predicts prognosis and reveals immune microenvironment infiltration in reclassified glioblastoma based on 2021 WHO classification.

ABSTRACT:

Background

Glioblastoma (GBM) is a highly malignant brain tumor with a poor prognosis. The WHO Classification of Tumors of the Central Nervous System (WHO CNS5) reclassified GBM in 2021. Pyroptosis, as an inflammatory form of programmed cell death, could regulate tumor cell proliferation, invasion, and metastasis. However, the role of pyroptosis in the newly defined GBM and its correlation with immunity have not yet been elucidated.

Method

According to the 2021 WHO CNS5, a total of 209 newly defined GBM samples from The Cancer Genome Atlas (TCGA) cohort were included for analysis. The Chinese Glioma Genome Atlas (CGGA) cohort was used as the validation set. The prognosis model was built by Least Absolute Shrinkage and Selection Operator (LASSO) Cox analysis. The nomogram was

SUBMITTER: Zheng X 

PROVIDER: S-EPMC12318951 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature