Sphingosine-1-phosphate alleviates colitis by regulating macrophage polarization and PI3k-Akt signaling.

ABSTRACT:

Introduction

Inflammatory bowel disease (IBD) is a complex disease that is characterized by tight junction loss and dysregulation of immune homeostasis. The repair of intestinal integrity and immune function in IBD remains a clinical challenge. Sphingosine-1-phosphate (S1P) has been reported to alleviate radiation-induced salivary gland damage by maintaining epithelial integrity. However, its potential to restore function during IBD has not yet been investigated.

Methods

Dextran sulfate sodium (DSS) was added to the drinking water of C57BL/6 mice for 5 days to induce colitis. Subsequently, S1P and vehicle were injected intravenously on days 1, 3, and 5. Body weight, the disease activity index (DAI), and the histological activity index (HAI) were recorded. The level of apopto

SUBMITTER: Hu L 

PROVIDER: S-EPMC12318956 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature