JMJD8 overexpression in breast cancer: implications for diagnosis, prognosis, and immune microenvironment interactions.

ABSTRACT:

Background

Breast cancer has severe consequences due to late diagnosis and the lack of effective therapies. Currently, potential biomarkers for breast cancer have not been systematically evaluated. Research has shown that JMJD8 is associated with cGAS-STING pathway and plays a role in various tumor microenvironments, but its relationship with breast cancer remains unclear. We investigate the relationship between JMJD8 and the prognosis and immune infiltration microenvironment of breast cancer, exploring its potential as a prognostic biomarker for this type of cancer.

Methods

In this study, we utilized data from The Cancer Genome Atlas (TCGA) to assess the association between JMJD8 expression and clinical characteristics in breast cancer (BRCA) patients through the Wilcoxon s

SUBMITTER: Zhu C 

PROVIDER: S-EPMC12318979 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature