Study on the mechanism of no. 8 burn ointment in burn treatment based on network pharmacology and experimental verification.

ABSTRACT:

Introduction

As a traditional Chinese compound formulation, No.8 burn ointment has demonstrated notable efficacy over half a century of clinical use, particularly in facilitating the healing of burn wounds.

Methods

This study integrates clinical data, liquid chromatography-mass spectrometry, network pharmacology and experimental validation to elucidate the mechanisms by which No.8 burn ointment promotes burn wound healing and to identify its key active components.

Results

The findings reveal that the ointment may accelerate wound repair by modulating the HIF-1 signaling pathway. The network pharmacology analysis has identified HIF-1α as a core target of the No.8 burn ointment's action and has identified the key active molecules β-Elemonic acid and Rubiadin, which inte

SUBMITTER: Qiu L 

PROVIDER: S-EPMC12319001 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature