Oncogenic CMTM6 drives M2a macrophages formation and fuels cervical cancer progression.

ABSTRACT:

Introduction

CMTM6, a member of the CKLF like MARVEL transmembrane (CMTM) gene family, has emerged as a critical orchestrator of oncogenic processes, yet its specific role in cervical cancer (CC) remains insufficiently characterized. Mounting evidence implicates that CMTM6 in sculpting an immunosuppressive tumor microenvironment (TME).

Methods

We investigated the expression and functional role of CMTM6 in CC cells using in vitro biological assays and a mouse xenograft model. The impact of CMTM6 on macrophage polarization and its association with tumor progression were systematically evaluated through a series of in vitro and in vivo experiments, focusing on the induction of M2a macrophage polarization and activation of the mTOR signaling pathway.

Results

Our results d

SUBMITTER: Yin B 

PROVIDER: S-EPMC12319053 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature