Immune characteristics and SALL1 methylation as prognostic biomarkers in primary and metastasis colorectal cancer.

ABSTRACT: Colorectal cancer (CRC) and its metastatic form (mCRC) demonstrate considerable biological and clinical heterogeneity. By analyzing transcriptomic data from CRC and mCRC patients, we identified significant differences in gene expression profiles between the two. Our study focused on immune-related differentially expressed genes, which enabled the classification of CRC patients into four distinct subgroups based on their gene expression patterns. These subgroups exhibited marked differences in overall survival (OS) and immune infiltration levels, with Group 1 characterized by a robust immune response.To refine prognostic assessment, we employed a LASSO regression model to select core genes and developed a risk scoring system with promising clinical utility. Furthermore, methylation analysis

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12319110 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature