WDFY4 Promotes the Progression of Atherosclerosis by Regulating Ferroptosis Mediated by the LAPTM5/CDC42/mTOR/4EBP1/SLC7A11 Pathway.

ABSTRACT: Atherosclerosis (AS) is a prevalent chronic inflammatory cardiovascular disease and leading cause of death worldwide. WD repeat and FYVE domain-containing 4 (WDFY4), a susceptibility gene for autoimmune diseases and reported AS hub gene, is associated with ferroptosis and inflammation. However, the mechanism by which WDFY4 affects atherosclerosis remains unclear. Here, WDFY4 was upregulated in oxidised low-density lipoprotein (ox-LDL)-treated cells and high-fat diet (HFD)-fed ApoE^-/- mice. Endothelium-specific transgenic mice were employed to disrupt the expression level of WDFY4 in vivo. WDFY4 knockdown inhibited ox-LDL-induced ferroptosis, cell injury and inflammation in HAECs in vitro. The STRING database predicted lysosomal transmembrane protein 5 (LAPTM5) as a WDFY4-interac

SUBMITTER: Zhong N 

PROVIDER: S-EPMC12319153 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature